It is an autoimmune disorder involving antibodies the subunit alpha of the postsynaptic nicotinic acetylcholine receptor at the neuromuscular junction leading to a decrease number of functional receptors.
With repeated simulation and decrease acetylcholine release, fatigue occurs.
The extent of involvement can be limited to ocular muscles, but muscles of respiration and swallowing can also be involved, causing distressed or aspiration
MG is associated with thymus hyperplasia, thymomas, or autoimmune disease such as thyroid disease, pernicious anemia and rheumatoid arthritis. MH also occurs in women’s with certain HLA types.
